Can cariprazine be used in autism spectrum disorder?

Cariprazine is not indicated for the use in autism spectrum disorder. Cariprazine has been used off label in autism spectrum disorder and intellectual disability disorder, as described in the published clinical report below.¹

A clinical trial investigating the pharmacokinetics, safety, and tolerability of cariprazine in paediatric participants with autism spectrum disorder aged 5-17 years was completed in December 2021.²

Further US studies to examine the effects of cariprazine on irritability and social aspects of this indication are planned.

References

1. Cohen LS, Pella C. Cariprazine in Autism Spectrum Disorder and Intellectual Disability Disorder. Global Journal of Intellectual & Developmental Disabilities 2019, 6(4), 71-75.
2. ClinicalTrials.gov Identifier: NCT04382885. https://clinicaltrials.gov/ct2/show/NCT04382885